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Human Disease
Human Disease
Human xeroderma pigmentosum group D gene encodes a DMA helicase
Genetics / DNA repair / Transcription Factors / Multidisciplinary / Nature / Saccharomyces cerevisiae / Humans / Cell fusion / Skin Cancer / Escherichia coli / Ultraviolet / Nucleotide Excision Repair / Proteins / Molecular cloning / Human Disease / Recombinant Proteins / DNA binding proteins / Xeroderma Pigmentosum / Adenosine Triphosphate / Saccharomyces cerevisiae / Humans / Cell fusion / Skin Cancer / Escherichia coli / Ultraviolet / Nucleotide Excision Repair / Proteins / Molecular cloning / Human Disease / Recombinant Proteins / DNA binding proteins / Xeroderma Pigmentosum / Adenosine Triphosphate
A diet-induced mouse model for glutaric aciduria type I
Magnetic Resonance Imaging / Diet / Survival Analysis / Brain / Mice / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions / Corpus striatum / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions / Corpus striatum
DNA Sequence and Comparative Genomics of pAPEC-O2-R, an Avian Pathogenic Escherichia coli Transmissible R Plasmid
Microbiology / Comparative Genomics / Medical Microbiology / Public Health / Food supply / Escherichia coli / Multidrug Resistance / Animals / Heavy Metal / GC content / Antimicrobial resistance / Human health / Chickens / Antimicrobial agents / Microbial Sensitivity Tests / Human Disease / Open Reading Frame / Quaternary Ammonium Compounds / DNA sequence / Escherichia coli / Multidrug Resistance / Animals / Heavy Metal / GC content / Antimicrobial resistance / Human health / Chickens / Antimicrobial agents / Microbial Sensitivity Tests / Human Disease / Open Reading Frame / Quaternary Ammonium Compounds / DNA sequence
Tumor-specific Th17-polarized cells eradicate large established melanoma
Clinical Trial / Biology / Medicine / T cell receptor / Mice / Melanoma / Animals / Blood / Clinical Sciences / MHC class II / Human Disease / Transgenic Mouse Technology / Interferon gamma / Melanoma / Animals / Blood / Clinical Sciences / MHC class II / Human Disease / Transgenic Mouse Technology / Interferon gamma
RDH12 and RPE65, Visual Cycle Genes Causing Leber Congenital Amaurosis, Differ in Disease Expression
Psychophysics / Blindness / Membrane Proteins / Optical coherence tomography / Adolescent / Biological Sciences / Protein Structure and Function / Vision / Humans / Child / Mutation / Retina / Retinal Degeneration / Genes / Middle Aged / Adult / Human Disease / Gene Disruption / Optical Coherence Tomography (OCT) Market / Gene Transfer / Dark Adaptation / Biological Sciences / Protein Structure and Function / Vision / Humans / Child / Mutation / Retina / Retinal Degeneration / Genes / Middle Aged / Adult / Human Disease / Gene Disruption / Optical Coherence Tomography (OCT) Market / Gene Transfer / Dark Adaptation
Study of pulmonary experimental paracoccidioidomycosis by analysis of bronchoalveolar lavage cells: resistant vs. susceptible mice
Plant Biology / Innate immunity / Mice / Animals / Male / Lung / Hydrogen Peroxide / Cellular Immunity / Human Disease / Somatic Cell Count / Enzyme Linked Immunosorbent Assay / Paracoccidioides / Bronchoalveolar lavage / Lung / Hydrogen Peroxide / Cellular Immunity / Human Disease / Somatic Cell Count / Enzyme Linked Immunosorbent Assay / Paracoccidioides / Bronchoalveolar lavage
In vivo protein transduction: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult
Genetics / Neuronal cell death / Free Radical / Hippocampus / Reactive Oxygen Species / Mice / Animals / Male / Peptides / Protein structure / Brain Ischemia / Neurons / Astrocytes / Epidermis / Superoxide Dismutase / Antioxidant enzyme / Molecular cloning / Amino Acid Profile / Biological activity / Reperfusion injury / Human Disease / Fusion Protein / Full Length Movies / Biochemistry and cell biology / Mice / Animals / Male / Peptides / Protein structure / Brain Ischemia / Neurons / Astrocytes / Epidermis / Superoxide Dismutase / Antioxidant enzyme / Molecular cloning / Amino Acid Profile / Biological activity / Reperfusion injury / Human Disease / Fusion Protein / Full Length Movies / Biochemistry and cell biology
A new preclinical femoral head osteonecrosis model in sheep
Magnetic Resonance Imaging / Sheep / Animals / Animal Model / Clinical Sciences / Gold Standard / Biological treatment / Disease Progression / Human Disease / Freezing / Gold Standard / Biological treatment / Disease Progression / Human Disease / Freezing
Infecciones fúngicas invasivas emergentes
Clinical Trial / Humans / Child / Fusarium / Fungal Infection / Antifungal Agents / Human Disease / Antifungal Agents / Human Disease
Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis
Electron Microscopy / Skeletal muscle biology / Gene Therapy / Immunohistochemistry / Confocal Microscopy / Brain / Female / Animals / Disease Severity / Electromyography / Synaptic Transmission / Fluorescent Antibody Technique / Rats / Myasthenia Gravis / Human Disease / Action Potentials / Individual Difference / Neuromuscular Junction / Radioimmunoassay / Brain / Female / Animals / Disease Severity / Electromyography / Synaptic Transmission / Fluorescent Antibody Technique / Rats / Myasthenia Gravis / Human Disease / Action Potentials / Individual Difference / Neuromuscular Junction / Radioimmunoassay
Epigenetic Regulation of Lentiviral Transgene Vectors in a Large Animal Model
Pharmacology / Genetics / Technology / HIV / Biological Sciences / Molecular / Animals / DNA methylation / CpG islands / Transgenic Animals / Animal Model / Swine / Histone deacetylase inhibitor / Human Disease / Human Fibroblasts / Transgene Expression / Hydroxamic Acids / Molecular Targeted Therapy / Gene Transfer / Histone deacetylase inhibitors / Histone deacetylases / Molecular / Animals / DNA methylation / CpG islands / Transgenic Animals / Animal Model / Swine / Histone deacetylase inhibitor / Human Disease / Human Fibroblasts / Transgene Expression / Hydroxamic Acids / Molecular Targeted Therapy / Gene Transfer / Histone deacetylase inhibitors / Histone deacetylases
Human disease classification in the postgenomic era: A complex systems approach to human pathobiology
Genomics / Systems Biology / Complex System / Humans / Disease / Molecular systems biology / Human Disease / Clinical Presentation / Molecular systems biology / Human Disease / Clinical Presentation
A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk
Research Design / Polymorphism / Population Genetics / Risk / Biological Sciences / Primates / Humans / Animals / Gene Dosage / Chromosome Disorders / Human Disease / Complex Structure / Comparative Genomic Hybridization / Primates / Humans / Animals / Gene Dosage / Chromosome Disorders / Human Disease / Complex Structure / Comparative Genomic Hybridization
Macrophage Plasticity in Experimental Atherosclerosis
Engineering / Physics / Chemistry / Biology / Atherosclerosis / Macrophages / Medicine / Multidisciplinary / Mice / Animals / PLoS one / Mouse Model / Cross Section / Cell Proliferation / Human Disease / Macrophages / Medicine / Multidisciplinary / Mice / Animals / PLoS one / Mouse Model / Cross Section / Cell Proliferation / Human Disease
Macrophage Plasticity in Experimental Atherosclerosis
Engineering / Physics / Chemistry / Biology / Atherosclerosis / Macrophages / Medicine / Multidisciplinary / Mice / Animals / PLoS one / Mouse Model / Cross Section / Cell Proliferation / Human Disease / Macrophages / Medicine / Multidisciplinary / Mice / Animals / PLoS one / Mouse Model / Cross Section / Cell Proliferation / Human Disease
DNA repair deficiency and neurological disease
Cognitive Science / DNA repair / Humans / Animals / Nervous System / Human Disease / Neurosciences / Nervous System Diseases / Human Disease / Neurosciences / Nervous System Diseases
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